19 Nov 2009
OBJECTIVE: To report the effect of dehydroepiandrosterone co-treatment on the outcome of controlled ovarian stimulation (COS) and timed intercourse (TIC) in women 35 years of age and older.
DESIGN: A cohort study.
MATERIAL AND METHODS: In 2 private practice centers, 136 infertile women ≥35 years of age were scheduled to undergo COS-TIC. Forty-four subjects have received 75 mg oral DHEA per day prior and during COS by cc or Letrozole ± FSH followed by HCG administration ant TIC. An age and basal FSH matched control group of 92 subjects treated by the same COS protocol without DHEA co-treatment was included. Both groups were compared regarding COS indices and pregnancy outcome.
RESULTS: DHEA treatment resulted in significantly more number of basal antral follicles at day 3 of the cycle compared with controls (mean ± SD 2.18 ± 1.18 versus 1.28 ± 0.96; respectively; P=0.0006). The number of the mature follicles (≥ 16 mm) at the day of HCG administration is significantly higher in the group treated by DHEA compared with the controls (P=0.007). On the other side, the mean serum level of the peakestradiol at the day of HCG administration is comparable between the two study groups of women co-treated with DHEA compared with controls (8/44 (18.2%) versus 4/92 (2.9%) respectively [P<0.001; RR 4.9 (CI 1.3-17.2)].
CONCLUSIONS: DHEA co-treatment has significantly modified the COS cycle characteristics without reducing PRs and could be of potential benefit in TIC cycles in older infertile women.