On this page you will find research and published papers by Drs. Ryan and Claessens and many other associates.  These papers deal with studies and findings related to infertility and its treatment.  Please read at your leisure as you will find many interesting and important facts to ponder.

Posting                   Publication
Date

9 Mar 2012    The Role of Androgen Supplementation in the Improvement of IVF Success Rates in Older Women - A 5 Year Experience   6 Nov 2011    THE USE OF D.H.E.A. IN WOMEN WITH D.O.R. / POOR OVARIAN RESPONDERS ( P.O.R.) / AND OLDER WOMEN TO IMPROVE THEIR FECUNDITY , REDUCE THEIR PREGNANCY LOSS AND CYCLE CANCELLATION RATES.   6 Nov 2011    Exogenous Androgens can improve pregnancy and take home baby rates in women over 40 yrs age ? Fact or Fiction. ABSTRACT:   Over the past several years , from many parts of the medical world there have been attempts made to improve the prognosis of women with diminished ovarian response , whether due to age or other factors. We hereby present more evidence that exogenous androgens may be pivotal in achieving this goal.         29 Sep 2010    AN ANALYSIS OF THE EFFECTS OF EXOGENOUS ANDROGEN ADMINISTRATION ON FERTILITY RATES IN DIFFERENT AGE GROUPS AND WITH DIFFERENT ADJUNCTIVE TREATMENTS.   1 Oct 2009    Dehydroepiandrosterone Co-Treatment in Infertile Women 35 Years Old and Older Receiveing Controlled Ovarian Stimulation and Timed Intercourse   1 Oct 2009    A Novel Method to Improve The Success Rate of I.V.F./I.C.S.I. in Older Woment With Diminshed Ovarian Reserve Supplemented With Dehydroepiandrosterone (DHEA)   1 Oct 2009    Dehydroplandrosterone (DHEA) Reduces Miscarriage Rates in Women With Diminished Ovarian Reserve: Multi-Center Study   1 Oct 2009    A Re-evaluation of the efficacy of C.O.H./I.U.I. in Older Women With Diminished Ovarian Reserve Supplemented With Dehydropiandrosterone (DHEA)   28 Sep 2009    Multi-Center Study on DHEA Supplementation in Women With Diminished Ovarian Reserve Reduces Spontaneous Miscarriage Rates   28 Sep 2009    The Sex Ratio of Offspring Born to Women Using Dehydroepiandrosterone (DHEA) to Improve Ovarian Response

Additional Research, Published Papers and Studies

1. Reported the smallest recorded case of fallopian tube carcinoma in literature;  American Journal of OBGYN., Vol 151 #2; pp 211-212, January, 1985.
    
2. Several articles on genital mycoplasma and its role in infertility, recurrent pregnancy loss and its medical treatment, 1980 - 1986.  Main author was Dr. Pat Quinn McArthur from The Hospital For Sick Children, Toronto, Ont., Canada.
    
3. Clinical research on Metformin in treating polycystic ovarian disease patients trying to get pregnant and effects on pregnancy after pregnancy is achieved.  Preliminary findings presented at the annual Hospital for Sick Children Research day in November, 2002.    
    
4. Case report on In-Vitro Maturation of immature oocytes in minimally stimulated ovaries and embryo quality . Presented at the American Fertility Society meeting in San Diego, November, 2000.  R. Chian, et al. 
    
5. Serologic evidence of Ureaplasma Urealyticum infections in women with spontaneous pregnancy loss.  Dr.'s Quinn P.A., Shewchuk K., Lie K.I., Ryan E., Sheu, Chipman M.L., et al.  American Journal OBGYN; January 15th, Vol 145 #2, pp 245-250.
    
6. Efficacy of antibiotic therapy in preventing spontaneous pregnancy loss among couples colonized with genital mycoplasma.  By Dr.'s Quinn P.A., Shewchuk A.B., Shuber J., Lie K.I., Ryan E., Chipman M.L., Nocilla D.M.  American Journal OBGYN; January 15th, 1983, Volume 145 #2, pp 239-244.
    
7. Prevalence of antibody to Chlamydia Trachomatis in spontaneous abortion and Infertility.  Quinn et al.
    
8. Efficacy of doxycycline in the eradication of mycoplasma from the genital tract of couples with reproductive failure; American Journal of OBGYN. Quinn et al.
    
9. Recurrence of genital mycoplasma infections in pregnancy, Proc. of 49th conjoint meeting on Infectious diseases, Ottawa, Ont. November 25-27, 1981.
    
10. Incidence of antibody to Chlamydia trachomatis in spontaneous abortion and infertility.  Quinn, et al.
     
11. Genital mycoplasma and their recurrence in spontaneous pregnancy loss.  Quinn, et al.  Presented at 1st International Conference on Ureaplasma Urealyticum infections, Seattle, WA.  October 10 - 12, 1985.
     
12. Abstract:  "A possible association between endometrial biopsy and increased implantation and pregnancy rate in subsequent frozen embryo transfer."  Esfandiari N., Claessens, E.A., Ryan, E., Gotlieb, L., Casper, R.F.A.  Presented at the A.S.R.M.  October 5. 16 - 20, 2004.  Philadelphia, PA.
     
13. Abstract:  "Pregnancy outcome in women with polycystic ovarian syndrome exposed to metformin."  Canadian Journal of Clinical Pharmacology, Volume 10, #3 - Autumn, 2003.
     
14. Effect of a statin on in-vitro model of endometriosis; Esfandiari N., Khazaei, M., A.I.J., Gotlieb, L., Ryan, E., Casper, R.F.  Fertility and Sterility, Volume 87, #2 - February 2007.
     
15. The presence of pinopods in the human endometrium does not delineate the implantation window.  Quinn, C.E., Ryan, E., Claessens, E.A., Greenblatt, E., et al.  Fertility and Sterility, Volume 87, #5 - May, 2007.
     
16. Expression of pinopods in the human endometrium during the secretology phase of the menstrual cycle.  Quinn, C.E., Ryan, E.A., Claessens, E.A., Greenblatt, E., Esfandiari, N., Casper, R.F.  Annual meeting of C.F.A. Society, Montreal, P.Q., Canada.  October 15 - 19, 2005.
     
17. Successful pregnancy following transfer of embryos from oocytes with abnormal zona pellucida and cytoplasmic morphology.  Esfandiari, N., Ryan, E., Gotlieb, L., Casper, R.F.  Fertility & Sterility, November 11, 2005.  Reproductive Biomedicine Online, 2005, Volume 11, #5 (555-561).
     
18. A possible association between endometrial biopsy and increased implantation rates in subsequent frozen embryo transfer.  Esfandiari, N., Claessens, E.A., Ryan, E., Casper, R.F., et al.  Abstract submission to A.S.R.M., 2004.
     
19. Pregnancy outcome after the use of metformin in PCOS patients.  Bedawy, M.A., Shabaan, O.M., Ryan, E., Casper, R.F.  Presented at A.S.R.M., Washington, D.C., October, 2007.
     
20. Dehydroepiandrosterone (DHEA) supplementation in women with diminished ovarian reserve reduces spontaneous miscarriage rates:  a multicentric study.  Ryan, E., Gleisher, B.D.; Toronto West Fertility Center; The Center for Human Reproduction, NYC Dep't of OBGYN; and Reproductive Sciences, Yale University, School of Medicine.  Submitted to E.S.H.R.E. in February 2008 as an abstract for the July 2008 annual meeting in Barcelona, Spain.
     
21. The effect of dehydroepiandrosterone co-treatment on the reproductive outcomes of women with previously unsuccessful ovulation induction.  Badawy, M., Ryan, E., Claessens, E.A., et al.  Cleveland Clinic; University of New York; Toronto West Fertility Center.  Submitted in February 2008 as an abstract for the E.S.H.R.E. annual meeting in July, 2008, Barcelona, Spain.
     
22. Dehydroepiandrosterone (DHEA) supplementation in women with diminished ovarian reserve reduces miscarriages.  Gleisher, N., Ryan, E., Barad, D.  Center for Human Reproduction, New York; Toronto West Fertility Center; Dep't of Epidemiology and Social Medicine and OBGYN, Albert Einstein College of Medicine, Bronx, N.Y.  Submitted to the New England Journal of Medicine for publication, March, 2008.
     
23. Abstract Submission:  Cryopreservation of human oocytes; freeze/thaw survival - embryo development and implantation following ICSI.  Forman, R.A., Esfandiari, N., Claessens, E.A., Ryan, E., Gotlieb, L., Casper, R.F.; TCART, Toronto, Ont.  Submitted to A.S.R.M., 2005.
     
24. Poster presentation at A.S.R.M. annual meeting in San Francisco on "The Sex Ratio of Babies Born to Mothers Who Conceived on DHEA".
    The Sex Ratio of Infants Born to Mothers Who Conceive on DHEA.  Fertility and Sterility, September 2008, Volume 90, Supplement S116-117.
     
25. Poster presentation with Drs Barad and Gleicher from the Center for Human Reproduction N.Y. and  Yale University, titled "DHEA reduces the miscarriage rate in women with diminished ovarian reserve", a multicentric study.  Presented at A.S.R.M. meeting in San Francisco, November, 2008.
     
26. Poster presentation accepted for the Canadian Fertility and Andrology Society Annual Meeting, November 18 - 21, 2009, Montreal, P.Q., Canada.  A re-evaluation of the efficacy of C.O.H./I.U.I. in older women with diminished ovarian reserve supplemented with DHEA.  Ryan, E., Claessens, E.A., et al.  Toronto West Fertility Center, Etobicoke, Ont., Canada.
     
27. Poster presentation accepted for the Canadian Fertility and Andrology Society Annual Meeting, November 18 - 21, 2009.  A novel method to improve the success rate of I.V.F. / I.C.S.I. in older women with diminished ovarian reserve supplemented with DHEA.  Claessens, E.A., Ryan, E., et al.  Toronto West Fertility Center, Etobicoke, Ont. Canada.
     
28. Poster presentation accepted for the American Fertility Society Annual Meeting in Atlanta, GA, October 17 - 21, 2009.  Dehydroepiandrosterone co-treatment in infertile women 35 years of age and older receiving controlled ovarian stimulation and timed intercourse.  Bedawy, M., Ryan, E., Shaaban, O., Claessens, E.A., Casper, R.F.
     
29. Miscarriage rates after DHEA supplementation in women with diminished ovarian reserve: a case control study.   Accepted on September 25, 2009 for publication by the Journal of Reproductive Biology and Endocrinology.  Gleicher, N., Ryan, E., et al.
30. "Pregnancy outcome after Metformin co-treatment in ovulation induction": Bedaiwy M, Ryan E et al, accepted for Dec.2009 publication in the Journal of the M.E.F.S.( Middle Eastern Fertility Society)
31. The role of Androgen supplementation in ovulation induction in older women.  Claessens E.A. Ryan E.A. et al Accepted for poster presentation at the International Society of Gynecological Endocrinology in Florence Italy March 2010. An analysis of C.O.H. with I.U.I. in women over 40 yrs age.
32.  THE USE OF D.H.E.A. IN WOMEN WITH D.O.R. / POOR OVARIAN RESPONDERS ( P.O.R.)  / AND OLDER WOMEN TO IMPROVE THEIR FECUNDITY , REDUCE THEIR PREGNANCY LOSS  AND CYCLE CANCELLATION RATES. Dr. Edward Ryan and A. Claessens. (CFAS Vancouver, September 2010)
33. Exogenous Androgens can improve pregnancy and take home baby rates in women over 40 yrs age ? Fact or Fiction. Dr. Anne Claessens1,2, Sonia Blanco Mejia1, Manuela Maroleanu1, Manuela Moruzanu1,Dr. Edward A Ryan1,2. (CFAS Toronto, September 2011)